T-cell-based immunosuppressive therapy inhibits the development of natural antibodies in infant baboons.
Transplantation
; 93(8): 769-76, 2012 Apr 27.
Article
en En
| MEDLINE
| ID: mdl-22441321
ABSTRACT
BACKGROUND:
We set out to determine whether B-cell tolerance to A/B-incompatible alloantigens and pig xenoantigens could be achieved in infant baboons.METHODS:
Artery patch grafts were implanted in the abdominal aorta in 3-month-old baboons using A/B-incompatible (AB-I) allografts or wild-type pig xenografts (pig). Group 1 (Gp1) (controls, n=6) received no immunosuppressive therapy (IS) and no graft. Gp2 (n=2) received an AB-I or pig graft but no IS. Gp3 received AB-I grafts+IS (Gp3A n=2) or pig grafts+IS (Gp3B n=2). IS consisted of ATG, anti-CD154mAb, and mycophenolate mofetil until age 8 to 12 months. Gp4 (n=2) received IS only but no graft.RESULTS:
In Gp1, anti-A/B and cytotoxic anti-pig immunoglobulin-M increased steadily during the first year. Gp2 became sensitized to donor-specific AB-I or pig antigens within 2 weeks. Gp3 and Gp4 infants that received anti-CD154mAb made no or minimal anti-A/B and anti-pig antibodies while receiving IS.DISCUSSION:
The production of natural anti-A/B and anti-pig antibodies was inhibited by IS with anti-CD154mAb, even in the absence of an allograft or xenograft, suggesting that natural antibodies may not be entirely T-cell independent. These data are in contrast to clinical experience with AB-I allotransplantation in infants, who cease producing only donor-specific antibodies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Inmunosupresores
/
Anticuerpos
/
Ácido Micofenólico
/
Suero Antilinfocítico
Límite:
Animals
Idioma:
En
Revista:
Transplantation
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos