GABA neurons of the VTA drive conditioned place aversion.
Neuron
; 73(6): 1173-83, 2012 Mar 22.
Article
en En
| MEDLINE
| ID: mdl-22445344
ABSTRACT
Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABA(A) receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence that driving GABA neurons with optogenetic effectors is sufficient to affect behavior. Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Área Tegmental Ventral
/
Condicionamiento Operante
/
Reacción de Fuga
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Neuronas Dopaminérgicas
/
Neuronas GABAérgicas
Idioma:
En
Revista:
Neuron
Asunto de la revista:
NEUROLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Suiza