Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder: a case study and review.
Immunohematology
; 27(3): 83-8, 2011.
Article
en En
| MEDLINE
| ID: mdl-22462101
ABSTRACT
AnWj is a high-incidence antigen present on the red blood cells (RBCs) of greater than 99 percent of the general population. A 58-year-old man underwent autologous hematopoietic stem cell transplantation (HSCT) for stage IVa mantle cell lymphoma. This procedure was complicated by failure to engraft, necessitating ongoing support with blood components. After a 2-month period of uneventful transfusion support, the patient experienced increasingly severe reactions with fever and evidence of intravascular hemolysis, including hemoglobinuria. Testing revealed a complement-dependent anti-AnWj. Phenotyping confirmed the AnWj- phenotype. Anti-AnWj was persistent despite immunosuppression, including treatment with allogeneic HSCT. Of interest, the pathogenesis of the downregulation of the graft AnWj in this patient is unclear.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos de Grupos Sanguíneos
/
Proteínas del Sistema Complemento
/
Trasplante de Células Madre Hematopoyéticas
/
Linfoma de Células del Manto
/
Eritrocitos
/
Rechazo de Injerto
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Immunohematology
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
HEMATOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Australia