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A novel antioxidant isobenzofuranone derivative from fungus Cephalosporium sp.AL031.
Huang, Xiang-Zhong; Zhu, Yun; Guan, Xiao-Li; Tian, Kai; Guo, Jun-Ming; Wang, Hong-Bin; Fu, Guang-Miao.
Afiliación
  • Huang XZ; Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China.
Molecules ; 17(4): 4219-24, 2012 Apr 05.
Article en En | MEDLINE | ID: mdl-22481542
Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7-methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 1-4 showed potent antioxidant activity with EC50 values of 10, 7, 22 and 5 µM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzofuranos / Acremonium / Antioxidantes Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzofuranos / Acremonium / Antioxidantes Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza