Biocompatibility of blood tubings.
Int J Artif Organs
; 13(10): 697-703, 1990 Oct.
Article
en En
| MEDLINE
| ID: mdl-2254048
We studied hemocompatibility of various blood tubings with C3a anaphylatoxin measurement and comparative electron scanning microscopy. The following tubing materials were tested: polyvinylchloride (PVC) plasticised with phthalate (PVC), pvc plasticised with phthalate coextruded with polyurethane (PIV), and two phthalate-free lines: pvc plasticised with trimellitate coextruded with polyurethane (TRI) and pvc plasticised with LT 360 (LTP). Results of C3a generation rate showed a significant activation by all blood tubings, with a reduced rate with PIV when compared to all others. Electron scanning microscopy showed marked alterations of PIV surface on tubings stored for 6 months. Protein deposits on internal surfaces after dialysis were similar whatever tubing material was tested, but adhesive cell number was greater with TRI when compared to PVC and LTP. Hemocompatibility is unchanged with phthalate-free tubings when compared to phthalate plasticised ones. In contrast with phthalate plasticised PVC there is no beneficial effect of polyurethane coextrusion with trimellitate plasticised PVC in regard to C3a generation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plastificantes
/
Materiales Biocompatibles
/
Diálisis Renal
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Artif Organs
Año:
1990
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Estados Unidos