Dissipation of sleep pressure is stable across adolescence.
Neuroscience
; 216: 167-77, 2012 Aug 02.
Article
en En
| MEDLINE
| ID: mdl-22554778
ABSTRACT
The sleep electroencephalogram (EEG) undergoes many changes during adolescence. We assessed whether sleep homeostasis is altered across adolescent development using two measures:
the dissipation of slow-wave activity (SWA, 0.6-4.6Hz) across the night and the rate of build-up of SWA in the first non-rapid eye movement (NREM) sleep episode. Furthermore, we examined the association between homeostatic and circadian measures, by correlating the build-up of SWA in the first non-rapid eye movement (NREM) sleep episode with circadian phase. Finally, we compared the dissipation of SWA in individuals with (PH+) and without (PH-) a parental history of alcohol abuse/dependence. Twenty children (8 PH+) and 25 teens (10 PH+) underwent two consecutive polysomnographic recordings at ages 9/10 and 15/16 years and again 1.5-3 years later. Thirteen young adults (ages 20-23 years; no PH+) were assessed one time. The decay of Process S was modeled for each individual at each assessment using data from both recordings. Four parameters of Process S were derived for EEG derivation C3/A2 time constant of the decay, lower asymptote (LA), the level of S at sleep onset (S(SO)), and S(SO) minus LA. We found no change in these parameters between assessments for the children and teen cohorts. Between-subject analysis of the follow-up assessment for children (ages 11-13 years) and the initial assessment for teens (ages 15/16 years) showed no difference in these parameters, nor did follow-up assessment of teens (ages 17-19 years) compared to the single assessment of young adults (ages 20-23 years). Similarly, we observed no developmental changes in the rate of the build-up of SWA in the first NREM sleep episode for our within- and between-subject analyses, or a correlation between this measure and circadian phase for either cohort. With regard to parental alcohol history, we found no difference in the dissipation of sleep pressure between PH+ and PH- children and teens. These results indicate that the dissipation of sleep pressure does not change across adolescent development, is not correlated with circadian phase, and does not differ between PH+ and PH- children and teens.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sueño
/
Encéfalo
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Neuroscience
Año:
2012
Tipo del documento:
Article
País de afiliación:
Suiza