One new antitumour cassane-type diterpene from Caesalpinia crista.

Tian, Qi-Jian; Ou, Yang-Hui; He, Xing-Bing; Jiang, Yong-Dong

Tian, Qi-Jian; Ou, Yang-Hui; He, Xing-Bing; Jiang, Yong-Dong.

Afiliación

Tian QJ; Key Laboratory of Plant Resources Conservation and Utilization of Hunan Province, Jishou University, Jishou 416000, China. tianqijian68@163.com

Nat Prod Res ; 27(6): 537-40, 2013.

Article en En | MEDLINE | ID: mdl-22578007

ABSTRACT

ABSTRACT

1α-acetoxy-5α, 7ß-dihydroxycassa-11,13(15)-diene-16,12-lactone, a new cassane-type diterpene was isolated from Caesalpinia crista. The structure of this compound was elucidated by analysis of NMR spectra, and the relative configuration was established by NOE experiment. The new compound was evaluated for antitumour activity against T47D, DU145 and showed significant inhibitory activities.

Asunto(s)

Antineoplásicos/química; Caesalpinia/química; Diterpenos/química; Antineoplásicos/farmacología; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Diterpenos/farmacología; Humanos; Espectroscopía de Resonancia Magnética; Estructura Molecular

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caesalpinia / Diterpenos / Antineoplásicos Límite: Humans Idioma: En Revista: Nat Prod Res Año: 2013 Tipo del documento: Article País de afiliación: China

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