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Bupropion and its main metabolite reverse nicotine chronic tolerance in the mouse.
Grabus, Sheri D; Carroll, Frank Ivy; Damaj, Mohamad Imad.
Afiliación
  • Grabus SD; Department of Pharmacology & Toxicology, Virginia Commonwealth University Medical Campus, Richmond, VA 23298-0524, USA.
Nicotine Tob Res ; 14(11): 1356-61, 2012 Nov.
Article en En | MEDLINE | ID: mdl-22589419
INTRODUCTION: Although the antidepressant bupropion is prescribed to aid in smoking cessation, little is known concerning its mechanisms of action in this regard. One factor that might influence quit success is nicotine tolerance, which could promote high levels of nicotine intake in order to maintain nicotine's subjective effects (thereby making attempts to reduce smoking more difficult). METHODS: To explore whether bupropion and its active hydroxymetabolite modulate nicotine tolerance, mice were injected for 14 days with saline or nicotine. On Day 14, animals received saline, (2S,3S)-hydroxybupropion, or bupropion at different doses. On Day 15, mice were assayed on test day for nicotine-induced analgesia and hypothermia. RESULTS: Animals chronically injected with saline + nicotine developed tolerance to nicotine's effects in both assays. Administration of bupropion and (2S,3S)-hydroxybupropion dose-dependently reversed chronic nicotine tolerance. CONCLUSIONS: These results indicate that bupropion's ability to promote smoking cessation may be partly due to its attenuation of nicotine tolerance since both measured responses of nicotine (antinociception and hypothermia) are mediated to a large extent by neuronal α4ß2* nicotine receptors.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bupropión / Tolerancia a Medicamentos / Nicotina Límite: Animals Idioma: En Revista: Nicotine Tob Res Asunto de la revista: SAUDE PUBLICA Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bupropión / Tolerancia a Medicamentos / Nicotina Límite: Animals Idioma: En Revista: Nicotine Tob Res Asunto de la revista: SAUDE PUBLICA Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido