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Persistent dose-dependent changes in brain structure in young adults with low-to-moderate alcohol exposure in utero.
Eckstrand, Kristen L; Ding, Zhaohua; Dodge, Neil C; Cowan, Ronald L; Jacobson, Joseph L; Jacobson, Sandra W; Avison, Malcolm J.
Afiliación
  • Eckstrand KL; Department of Radiology and Radiological Sciences , Vanderbilt University Medical Center, Nashville, TN, USA.
Alcohol Clin Exp Res ; 36(11): 1892-902, 2012 Nov.
Article en En | MEDLINE | ID: mdl-22594302
BACKGROUND: Many children with heavy exposure to alcohol in utero display characteristic alterations in brain size and structure. However, the long-term effects of low-to-moderate alcohol exposure on these outcomes are unknown. METHODS: Using voxel-based morphometry and region-of-interest analyses, we examined the influence of lower doses of alcohol on gray and white matter composition in a prospectively recruited, homogeneous, well-characterized cohort of alcohol-exposed (n = 11, age 19.5 ± 0.3 years) and control (n = 9, age 19.6 ± 0.5 years) young adults. A large proportion of the exposed individuals were born to mothers whose alcohol consumption during pregnancy was in the low-to-moderate range. RESULTS: There were no differences in total brain volume or total gray or white matter volume between the exposed and control groups. However, gray matter volume was reduced in alcohol-exposed individuals in several areas previously reported to be affected by high levels of exposure, including the left cingulate gyrus, bilateral middle frontal gyri, right middle temporal gyrus, and right caudate nucleus. Notably, this gray matter loss was dose dependent, with higher exposure producing more substantial losses. CONCLUSIONS: These results indicate that even at low doses, alcohol exposure during pregnancy impacts brain development and that these effects persist into young adulthood.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Encéfalo / Consumo de Bebidas Alcohólicas / Etanol Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Pregnancy Idioma: En Revista: Alcohol Clin Exp Res Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Encéfalo / Consumo de Bebidas Alcohólicas / Etanol Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Pregnancy Idioma: En Revista: Alcohol Clin Exp Res Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido