Professional exposure to goats increases the risk of pneumonic-type lung adenocarcinoma: results of the IFCT-0504-Epidemio study.
PLoS One
; 7(5): e37889, 2012.
Article
en En
| MEDLINE
| ID: mdl-22655078
ABSTRACT
Pneumonic-type lung adenocarcinoma (P-ADC) represents a distinct subset of lung cancer with specific clinical, radiological, and pathological features. Given the weak association with tobacco-smoking and the striking similarities with jaagsiekte sheep retrovirus (JSRV)-induced ovine pulmonary adenocarcinoma, it has been suggested that a zoonotic viral agent infecting pulmonary cells may predispose to P-ADC in humans. Our objective was to explore whether exposure to domestic small ruminants may represent a risk factor for P-ADC. We performed a multicenter case-control study recruiting patients with P-ADC as cases and patients with non-P-ADC non-small cell lung cancer as controls. A dedicated 356-item questionnaire was built to evaluate exposure to livestock. A total of 44 cases and 132 controls were included. At multivariate analysis, P-ADC was significantly more associated with female gender (Odds-ratio (OR)â=â3.23, 95% confidence interval (CI) 1.32-7.87, pâ=â0.010), never-smoker status (ORâ=â3.57, 95% CI 1.27-10.00, pâ=â0.015), personal history of extra-thoracic cancer before P-ADC diagnosis (ORâ=â3.43, 95% CI 1.10-10.72, pâ=â0.034), and professional exposure to goats (ORâ=â5.09, 95% CI 1.05-24.69, pâ=â0.043), as compared to other subtypes of lung cancer. This case-control suggests a link between professional exposure to goats and P-ADC, and prompts for further epidemiological evaluation of potential environmental risk factors for P-ADC.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cabras
/
Adenocarcinoma
/
Exposición a Riesgos Ambientales
/
Ganado
/
Neoplasias Pulmonares
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Animals
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Child
/
Child, preschool
/
Female
/
Humans
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Infant
/
Male
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Middle aged
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Francia