The effect of posterior tooth loss on the expression of type II collagen, IL-1ß and VEGF in the condylar cartilage of growing rats.
Arch Oral Biol
; 57(11): 1551-7, 2012 Nov.
Article
en En
| MEDLINE
| ID: mdl-22658342
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate the effect of unilateral and bilateral loss of posterior occlusal support on the expression of type II collagen, interleukin-1ß and VEGF in the condylar cartilage of growing rats.DESIGN:
Thirty female Wistar rats (5 weeks old) were randomized into three groups control, unilateral extraction of mandibular molar teeth, bilateral extraction of mandibular molar teeth. Animals were sacrificed 8 weeks after tooth extraction and the temporomandibular joints were prepared for immunohistochemical analysis.RESULTS:
Bilateral molar extraction increased the expression of interleukin-1ß (P<0.01) and VEGF (P<0.01), while unilateral extraction increased the expression of interleukin-1ß (P<0.05) and type II collagen (P<0.01). The expression of VEGF was higher on the extracted than on the non-extracted side (P<0.01) after unilateral extraction.CONCLUSION:
Loss of posterior occlusal support alters the expression of type II collagen, interleukin-1ß and VEGF in the condylar cartilage of rats. The expression pattern of these proteins is different when loss of occlusal support was bilateral or unilateral, including differences between extracted and non-extracted sides.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Articulación Temporomandibular
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Cartílago
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Pérdida de Diente
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Colágeno Tipo II
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Factor A de Crecimiento Endotelial Vascular
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Interleucina-1beta
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Cóndilo Mandibular
Límite:
Animals
Idioma:
En
Revista:
Arch Oral Biol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Brasil