Cytotoxic and NF-κB inhibitory sesquiterpene lactones from Piptocoma rufescens.
Tetrahedron
; 68(12): 2671-2678, 2012 Mar 25.
Article
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| MEDLINE
| ID: mdl-22685350
ABSTRACT
Six new (1-6) and eight known germacranolide-type sesquiterpene lactones, along with several known phenylpropanol coumarates and methylated flavonoids, were isolated from the leaves of Piptocoma rufescens, collected in the Dominican Republic. The new compounds were identified by analysis of their spectroscopic data, with the molecular structure of 3 being established by single-crystal X-ray diffraction. The absolute configurations of the sesquiterpene lactones isolated were determined from their CD and NOESY NMR spectra, together with the analysis of Mosher ester reactions. Bioassay screening results showed the majority of the sesquiterpene lactones isolated (1-13) to be highly cytotoxic toward the HT-29 human colon cancer cell line, with the most potent compound being 15-deoxygoyazensolide (10, IC(50), 0.26 µM). In addition, several of the sesquiterpene lactones exhibited NF-κB (p65) inhibitory activity.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Tetrahedron
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos