Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method.
Nanoscale
; 4(15): 4426-9, 2012 Aug 07.
Article
en En
| MEDLINE
| ID: mdl-22688679
ABSTRACT
We report the investigation of the mechanical properties of different types of amyloid fibrils by the peak force quantitative nanomechanical (PF-QNM) technique. We demonstrate that this technique correctly measures the Young's modulus independent of the polymorphic state and the cross-sectional structural details of the fibrils, and we show that values for amyloid fibrils assembled from heptapeptides, α-synuclein, Aß(1-42), insulin, ß-lactoglobulin, lysozyme, ovalbumin, Tau protein and bovine serum albumin all fall in the range of 2-4 GPa.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nanotecnología
/
Amiloide
Límite:
Animals
Idioma:
En
Revista:
Nanoscale
Año:
2012
Tipo del documento:
Article
País de afiliación:
Suiza