Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes.
BMC Res Notes
; 5: 299, 2012 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-22709668
ABSTRACT
BACKGROUND:
The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy.RESULTS:
The extract of Cinnamomum zeylanicum against Escherichia coli ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 µg/ml. The extract of Dorstenia psilurus was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine-ß- Naphtylamide (PAßN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with erythromycin (ERY).CONCLUSION:
The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Solventes
/
Bacterias
/
Extractos Vegetales
/
Especias
/
Metanol
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Antibacterianos
País/Región como asunto:
Africa
Idioma:
En
Revista:
BMC Res Notes
Año:
2012
Tipo del documento:
Article