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Relation between microRNA expression in peritoneal dialysis effluent and peritoneal transport characteristics.
Chen, Jin; Kam-Tao, Philip; Kwan, Bonnie Ching-Ha; Chow, Kai-Ming; Lai, Ka-Bik; Luk, Cathy Choi-Wan; Szeto, Cheuk-Chun.
Afiliación
  • Chen J; Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Dis Markers ; 33(1): 35-42, 2012.
Article en En | MEDLINE | ID: mdl-22710867
BACKGROUND: The role of microRNAs (miRNAs) in peritoneal transport is uncertain. METHODS: We studied 82 new peritoneal dialysis (PD) patients, 22 prevalent patients without ultrafiltration problem, and 6 patients with documented ultrafiltration problem. Peritoneal transport was determined by standard peritoneal equilibration test (PET). RNA was extracted from the PD effluent after PET, and intra-peritoneal expression of miRNA targets were quantified. RESULTS: There were significant difference in the PDE expressions of miR-15a and miR-21. There were modest inverse correlations between ultrafiltration volume and PDE expression of miR-17 (r= -0.198, p =0.041) and miR-377 (r=-0.201, p=0.041). There was an inverse correlations between dialysate-to-plasma creatinine concentration at 4 hours and PDE expression of miR-192 (r=-0.199, p=0.040); while mass transfer area coefficient of creatinine correlated with PDE expression of miR-192 (r=-0.191, p=0.049) and miR-377 (r=0.201, p=0.041). Amongst 7 randomly selected patients who had repeat PET after one year, there was a significant correlation between baseline PDE expression of miR-377 and change in ultrafiltration volume (r=-0.852, p=0.015). CONCLUSION: The miRNA expression in PDE, including miR-15a, miR-17, miR-21, miR-30, miR-192, and miR-377, correlated with peritoneal transport characteristics. Our result suggests that miRNA may play a role in the regulation of peritoneal membrane function.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Peritoneal / MicroARNs Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Dis Markers Asunto de la revista: BIOQUIMICA Año: 2012 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Peritoneal / MicroARNs Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Dis Markers Asunto de la revista: BIOQUIMICA Año: 2012 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos