T-cell immune monitoring by the ELISPOT assay for interferon gamma.
Clin Chim Acta
; 413(17-18): 1359-63, 2012 Sep 08.
Article
en En
| MEDLINE
| ID: mdl-22732764
ABSTRACT
The enzyme-linked immunosorbent spot (ELISPOT) assay for interferon gamma has been available for more than twenty years and has been used for a number of applications, including the monitoring of T cell immunity in solid organ transplant recipients. Studies from single centers indicate that heightened T cell alloreactivity measured with this assay correlates with acute and chronic rejection and with poor long-term allograft function. The assay has been used not only to assess T cell reactivity after transplantation, but also as a tool for assessing immune risk prior to transplantation. Additional work is needed to validate the assay in larger multicenter clinical trials.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ensayo de Inmunoadsorción Enzimática
/
Linfocitos T
/
Monitorización Inmunológica
/
Interferón gamma
Tipo de estudio:
Clinical_trials
/
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Chim Acta
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos