Comparison of two ready-to-use systems designed for sperm-hyaluronic acid binding selection before intracytoplasmic sperm injection: PICSI vs. Sperm Slow: a prospective, randomized trial.
Fertil Steril
; 98(3): 632-7, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-22749221
ABSTRACT
OBJECTIVE:
To compare, in a strict, randomized way, the efficiency of two ready-to-use systems for hyaluronic acid (HA)-intracytoplasmic sperm injection (ICSI) an HA culture dish (PICSI Sperm Selection Device) and a viscous medium containing HA (Sperm Slow).DESIGN:
Prospective, randomized study.SETTING:
Medical center. PATIENT(S) Fifty subjects per treatment group (100 total). INTERVENTION(S) One hundred ICSI treatments were randomly carried out with PICSI or with Sperm Slow for sperm selection. Randomization was conducted with sealed envelopes. Intracytoplasmic sperm injection was performed by a single embryologist with 5 years' experience in HA-ICSI. PRIMARY OUTCOMEMEASURE:
good-quality embryo rate. SECONDARY OUTCOMEMEASURES:
oocyte fertilization, pregnancy and implantation rate, and the duration of the ICSI procedure. RESULT(S) The good-quality embryo rate was comparable between the two groups (58.5% with PICSI vs. 56% with Sperm Slow). Overall there were no statistically significant differences in secondary outcome measures except ICSI procedure duration, which was 3 minutes longer in the PICSI group. CONCLUSION(S) Both PICSI and Sperm Slow allow comparable clinical efficiency in selecting HA-bound spermatozoa. CLINICAL TRIAL REGISTRATION NUMBER ISRCTN72668039.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inyecciones de Esperma Intracitoplasmáticas
/
Ácido Hialurónico
Tipo de estudio:
Clinical_trials
/
Observational_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Fertil Steril
Año:
2012
Tipo del documento:
Article
País de afiliación:
Italia