Ral inhibits ligand-independent Notch signaling in Drosophila.
Small GTPases
; 3(3): 186-91, 2012.
Article
en En
| MEDLINE
| ID: mdl-22750761
ABSTRACT
We discovered recently that the Drosophila Ral GTPase regulates Notch signaling and thereby affects cell patterning in the eye. Although Ral functions in the ligand signaling cells, Ral does not stimulate ligand signaling directly. Rather, in cells that express both Notch receptor and ligand, Ral activity promotes a cell to become the signaler by inhibiting Notch receptor activation in that cell. Moreover, Ral inhibits a particular pathway of Notch activation-receptor activation that occurs independent of ligand binding. In this Commentary, we discuss the phenomenon of ligand-independent Notch receptor activation and how this event might be regulated by Ral.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Proteínas de Unión al GTP ral
/
Proteínas de Drosophila
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Drosophila
/
Receptores Notch
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Ojo
Límite:
Animals
Idioma:
En
Revista:
Small GTPases
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos