The expression and modulation of CEACAM1 and tumor cell transformation.
Ann Ist Super Sanita
; 48(2): 161-71, 2012.
Article
en En
| MEDLINE
| ID: mdl-22751559
ABSTRACT
BACKGROUND:
In this review, we focus our discussion on one class of carcinoembryonic antigen- related cell adhesion molecules, Carcinoembryonic antigen-related cell adhesion molecules 1 (CEACAM1). This has been observed in several malignant transformations to be subjected to complex mechanisms of modulation and dysregulation.AIMS:
Restoration of CEACAM1 expression in tumor cell lines often abolishes their oncogenicity in vivo, and therefore, this adhesion molecule has been regarded as a tumor suppressor. In contrast, de novo expression of CEACAM1 is found with the progression of malignancy and metastatic spread in a large array of cancer tissues which include melanoma, Non Small Cell Lung Carcinoma (NSCLC) as well as bladder, prostate, thyroid, breast, colon and gastric carcinomas.DISCUSSION:
We report and discuss the most significant findings confirming at immunohistochemical and clinical level the correlation between poor prognosis and expression of CEACAM1 on the cell surface of tumors.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos CD
/
Moléculas de Adhesión Celular
/
Regulación Neoplásica de la Expresión Génica
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Transformación Celular Neoplásica
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Proteínas Supresoras de Tumor
/
Proteínas de Neoplasias
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Ann Ist Super Sanita
Año:
2012
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
IT
/
ITALIA
/
ITALY
/
ITÁLIA