Stereoselective glycosylation of glucosamine: the role of the N-protecting group.
Chem Asian J
; 7(11): 2482-501, 2012 Nov.
Article
en En
| MEDLINE
| ID: mdl-22753270
ABSTRACT
Oligosaccharides and glycoconjugates play an important role in biological processes. The use of these complex polymers as biocompatible materials for medicinal applications as well as therapeutic agents for the treatment of several diseases has attracted considerable interest. However, these investigations require large and pure amounts of glycostructures. Glucosamine is one of the major building blocks of these highly important glycoconjugates. Recently, considerable synthetic efforts have been devoted to improving stereoselective glycosylation. In this Focus review, the role of the amine protecting group in the outcome of the glucosamine glycosylation reaction is highlighted.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glucosamina
Idioma:
En
Revista:
Chem Asian J
Año:
2012
Tipo del documento:
Article
País de afiliación:
Portugal