Review of the biologic agents used for immune-mediated inner ear disease.
Acta Otorrinolaringol Esp
; 64(3): 223-9, 2013.
Article
en En, Es
| MEDLINE
| ID: mdl-22770424
ABSTRACT
INTRODUCTION AND OBJECTIVES:
Immune-mediated inner ear disease (IMIED) is one of the few reversible forms of sensorineural hearing loss. Treatment is based on high-dose corticosteroids, although long-term therapy is associated with serious adverse effects; this has led to the use of other agents or different routes of administration such as transtympanic delivery. This study analyses the role of biological agents in IMIED management. MATERIAL ANDMETHODS:
We searched PUBMED for studies that examined the response to treatment with different biological agents in patients with IMIED. The following data were extracted from the selected studies and entered into a standardised database exclusion and inclusion criteria, characteristics of the patients studied, treatment, outcome measures and response rates achieved.RESULTS:
Thirteen studies were included in this review. A TNF alpha inhibitor (etanercept, infliximab, adalimumab) was used in 8 studies, an IL-1 antagonist (anakinra) was used in 3 studies and rituximab, an antibody directed against the CD20 surface antigen on B lymphocytes, was evaluated in 2 studies. Most studies achieved a hearing improvement or stabilisation in more than 70% of treated patients.CONCLUSIONS:
Biological agents can play a role in the management of patients with IMIED, at least in those patients who do not respond to conventional therapy or whose hearing is not stabilised. However, specially-designed randomised controlled clinical trials are needed to assess their effectiveness.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factores Biológicos
/
Enfermedades del Laberinto
Tipo de estudio:
Clinical_trials
/
Systematic_reviews
Límite:
Humans
Idioma:
En
/
Es
Revista:
Acta Otorrinolaringol Esp
Año:
2013
Tipo del documento:
Article