Role of testosterone in managing advanced prostate cancer.
Urology
; 80(4): 754-62, 2012 Oct.
Article
en En
| MEDLINE
| ID: mdl-22795376
ABSTRACT
Androgen deprivation therapy is frequently used to treat patients with advanced prostate cancer. New therapies for metastatic castration-resistant prostate cancer have drawn increased attention to serum and intratumoral testosterone levels. The present review examines the role of testosterone in prostate cancer progression, discusses the nuances and potential pitfalls in measuring serum testosterone using available assays, and summarizes current data relevant to the arguments for and against achieving and maintaining the lowest possible testosterone levels during androgen deprivation therapy, including the adverse effects of such treatment. Incorporating this information, we have made recommendations incorporating testosterone evaluation and its effect on the clinical decision-making process.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Testosterona
/
Hormona Liberadora de Gonadotropina
/
Antagonistas de Andrógenos
Tipo de estudio:
Guideline
/
Prognostic_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Urology
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos