Central and peripheral quadriceps fatigue in congestive heart failure.
Int J Cardiol
; 167(6): 2594-9, 2013 Sep 10.
Article
en En
| MEDLINE
| ID: mdl-22795722
ABSTRACT
AIMS:
The clinical syndrome of heart failure includes exercise limitation that is not directly linked to measures of cardiac function. Quadriceps fatigability may be an important component of this and this may arise from peripheral or central factors. METHODS ANDRESULTS:
We studied 10 men with CHF and 10 healthy age-matched controls. Compared with a rest condition, 10 min after incremental maximal cycle exercise, twitch quadriceps force in response to supramaximal magnetic femoral nerve stimulation fell in both groups (CHF 14.1% ± 18.1%, p=0.037; CONTROL 20.8 ± 11.0%, p<0.001; no significant difference between groups). There was no significant change in quadriceps maximum voluntary contraction voluntary force. The difference in the motor evoked potential (MEP) response to transcranial magnetic stimulation of the motor cortex between rest and exercise conditions at 10 min, normalised to the peripheral action potential, also fell significantly in both groups (CHF 27.3 ± 38.7%, p=0.037; CONTROL 41.1 ± 47.7%, p=0.024). However, the fall in MEP was sustained for a longer period in controls than in patients (p=0.048).CONCLUSIONS:
The quadriceps is more susceptible to fatigue, with a similar fall in TwQ occurring in CHF patients at lower levels of exercise. This is associated with no change in voluntary activation but a lesser degree of depression of quadriceps motor evoked potential.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fatiga Muscular
/
Músculo Cuádriceps
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Estimulación Magnética Transcraneal
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Prueba de Esfuerzo
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Insuficiencia Cardíaca
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Contracción Muscular
Tipo de estudio:
Clinical_trials
Límite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Int J Cardiol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Reino Unido