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Hypoglycemic effects of hyaluronate-endo-ß-N-acetylhexosaminidase immobilized by electron beam synthesis nanotechnology.
Dygai, A M; Zyuz'kov, G N; Zhdanov, V V; Udut, E V; Miroshnichenko, L A; Khrichkova, T J; Simanina, E V; Stavrova, L A; Gurto, R V; Minakova, M Yu; Chajkovskij, A V; Markova, T S; Artamonov, A V; Bekarev, A A; Madonov, P G; Kinsht, D N.
Afiliación
  • Dygai AM; Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
Bull Exp Biol Med ; 153(1): 94-7, 2012 May.
Article en En | MEDLINE | ID: mdl-22808503
ABSTRACT
Hypoglycemic effect of hyaluronate-endo-ß-N-acetylhexosaminidase immobilized by electron-beam synthesis nanotechnology (imHEA-HA) was studied in experimental insulin-dependent and insulin-independent diabetes mellitus. The drug exhibited a hypoglycemic effect of its own and potentiated the pharmacological effect of exogenous insulin injected in vivo. Studies on liver cell culture demonstrated an increase of cell sensitivity to insulin after treatment with imHEA-HA.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Beta-N-Acetilhexosaminidasas / Nanotecnología / Enzimas Inmovilizadas / Glicosaminoglicanos / Hipoglucemiantes Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2012 Tipo del documento: Article País de afiliación: Rusia
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Beta-N-Acetilhexosaminidasas / Nanotecnología / Enzimas Inmovilizadas / Glicosaminoglicanos / Hipoglucemiantes Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2012 Tipo del documento: Article País de afiliación: Rusia