Determination of strong ion gap in healthy dogs.
J Vet Emerg Crit Care (San Antonio)
; 22(4): 447-52, 2012 Aug.
Article
en En
| MEDLINE
| ID: mdl-22809147
ABSTRACT
OBJECTIVE:
To determine and compare reference intervals of the strong ion gap (SIG) in a group of healthy dogs determined with 2 different equations.DESIGN:
Prospective observational study.SETTING:
Tertiary referral and teaching hospital. ANIMALS Fifty-four healthy dogs.INTERVENTIONS:
None. MEASUREMENTS Serum biochemistry and blood gas analyses were performed for each dog. From these values, SIG was calculated using 2 different equations SIG(1) = SID(a) {[Na (+)] + [K(+)] - [Cl(-)]+ [2 × Ca(2+)] + [2 × Mg(2+)] - [L-lactate]}- SID(e) {TCO(2) + A(-)} and SIG(2) = [albumin] × 4.9-anion gap. Reference intervals were established for each SIG equation using the mean ± 1.96 × standard deviation (SD).RESULTS:
For SIG(1), the median was 7.13 mEq/L (range, 1.05-11.30 mEq/L) and the derived reference interval was 1.85-10.61 mEq/L. Median SIG(2) was -0.22 mEq/L (range, -5.34-6.61 mEq/L) and the mean SIG(2) was -0.09 mEq/L (95% confidence interval for the mean, -0.82-0.65 mEq/L). The derived reference interval was -5.36-5.18 mEq/L. The results of the SIG calculations were significantly different (P < 0.0001) between the 2 equations used.CONCLUSION:
The 2 equations used to calculate SIG yielded significantly different results and cannot be used interchangeably. The authors believe SIG(2) to be a more accurate reflection of acid-base status in healthy dogs, and recommend that this calculation be used for future studies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Equilibrio Ácido-Base
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Perros
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Electrólitos
Tipo de estudio:
Observational_studies
Límite:
Animals
Idioma:
En
Revista:
J Vet Emerg Crit Care (San Antonio)
Asunto de la revista:
MEDICINA DE EMERGENCIA
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MEDICINA VETERINARIA
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TERAPIA INTENSIVA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos