Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies.
Int J Hyperthermia
; 28(6): 509-17, 2012.
Article
en En
| MEDLINE
| ID: mdl-22834701
ABSTRACT
Local hyperthermia is an effective treatment modality to augment radio- and chemotherapy-based anti-cancer treatments. Although the effect of hyperthermia is pleotropic, recent experiments revealed that homologous recombination, a pathway of DNA repair, is directly inhibited by hyperthermia. The hyperthermia-induced DNA repair deficiency is enhanced by inhibitors of the cellular heat-shock response. Taken together, these results provide the rationale for the development of novel anti-cancer therapies that combine hyperthermia-induced homologous recombination deficiency with the systemic administration of drugs that specifically affect the viability of homologous recombination deficient cells and/or inhibit the heat-shock response, to locally sensitise cancer cells to DNA damaging agents.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Reparación del ADN
/
Trastornos por Deficiencias en la Reparación del ADN
/
Hipertermia Inducida
Límite:
Humans
Idioma:
En
Revista:
Int J Hyperthermia
Asunto de la revista:
NEOPLASIAS
/
TERAPEUTICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Países Bajos