Astragalus polysaccharide and sulfated epimedium polysaccharide synergistically resist the immunosuppression.
Carbohydr Polym
; 90(2): 1055-60, 2012 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-22840039
ABSTRACT
The immunoenhancement of compound polysaccharides, APS-sEPS composed with astragalus polysaccharide (APS) and sulfated epimedium polysaccharide (sEPS), was observed in immunosuppressed model chicken induced by cyclophosphamide (Cy). 11-day-old chickens were injected with Cy once a day for three successive days except vaccine control group. At day-14-old, all chickens were vaccinated with ND vaccine, and in experimental groups simultaneously administrated with APS-sEPS at three dosages, APS and sEPS once a day for three successive days. On days 7, 14, 21 and 28 after the administration, the peripheral T-lymphocyte proliferation, serum antibody titers, IFN-γ, IL-2, IgG and IgM were determined. The results displayed that APS-sEPS could overcome Cy-induced immunosuppression, significantly promote T-lymphocyte proliferation and raised serum antibody titers, IFN-γ, IL-2, IgG and IgM levels, its high and medium doses were superior to single APS or sEPS. This demonstrated that APS and sEPS could synergistically resist the immunosuppression and APS-sEPS was an effective immunopotentiator.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polisacáridos
/
Planta del Astrágalo
/
Epimedium
/
Tolerancia Inmunológica
Tipo de estudio:
Evaluation_studies
Límite:
Animals
Idioma:
En
Revista:
Carbohydr Polym
Año:
2012
Tipo del documento:
Article