Coagulation and survival in Drosophila melanogaster fondue mutants.
J Insect Physiol
; 58(10): 1376-81, 2012 Oct.
Article
en En
| MEDLINE
| ID: mdl-22885376
ABSTRACT
Drosophila larval coagulation factors have been identified in vitro. Better understanding of insect hemolymph coagulation calls for experiments in vivo. We have characterized a fondue (fon) mutation and null alleles isolated by imprecise excision of a transposable element. Loss of fon was pupal lethal, but adults could be recovered by expressing the UASfonGFP construct of Lindgren et al. (2008). Despite their lethality, fon mutations did not affect larval survival after wounding either when tested alone or in combination with a mutation in the hemolectin clotting factor gene. This reinforces the idea of redundant hemostatic mechanisms in Drosophila larvae, and independent pleiotropic functions of the fondue protein in coagulation and a vital process in metamorphosis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Sanguíneas
/
Hemolinfa
/
Proteínas de Drosophila
/
Drosophila melanogaster
/
Hemostasis
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Insect Physiol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos