A perioperative smoking cessation intervention with varenicline: a double-blind, randomized, placebo-controlled trial.
Anesthesiology
; 117(4): 755-64, 2012 Oct.
Article
en En
| MEDLINE
| ID: mdl-22890119
ABSTRACT
BACKGROUND:
The efficacy of perioperative tobacco interventions on long-term abstinence and the safety of smoking cessation less than 4 weeks before surgery is unclear. Our objective was to determine the efficacy and safety of a perioperative smoking cessation intervention with varenicline to reduce smoking in elective surgical patients.METHODS:
In a prospective, multicenter, double-blind, placebo-controlled trial, 286 patients were randomized to receive varenicline or placebo. Both groups received in-hospital and telephone counseling during 12 months. The primary outcome was the 7-day point prevalence abstinence rate 12 months after surgery. Secondary outcomes included abstinence at 3 and 6 months after surgery. Multivariable logistic regression was used to identify independent variables related to abstinence.RESULTS:
The 7-day point prevalence abstinence at 12 months for varenicline versus placebo was 36.4% versus 25.2% (relative risk 1.45; 95% CI 1.01-2.07; P = 0.04). At 3 and 6 months, the 7-day point prevalence abstinence was 43.7% versus 31.9% (relative risk 1.37; 95% CI 1.01 to 1.86; P = 0.04), and 35.8% versus 25.9% (relative risk 1.43; 95% CI 1.01-2.04; P = 0.04) for varenicline versus placebo, respectively. Treatment with varenicline (odds ratio 1.76; 95% CI 1.03-3.01; P = 0.04), and preoperative nicotine dependence (odds ratio 0.82, 95% CI 0.68 to 0.98; P = 0.03) predicted abstinence at 12 months. The adverse events profile in both groups was similar except for nausea, which occurred more frequently for varenicline versus placebo (13.3% vs. 3.7%, P = 0.004).CONCLUSIONS:
A perioperative smoking cessation intervention with varenicline increased abstinence from smoking 3, 6, and 12 months after elective noncardiac surgery with no increase in serious adverse events.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinoxalinas
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Benzazepinas
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Cese del Hábito de Fumar
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Atención Perioperativa
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Anesthesiology
Año:
2012
Tipo del documento:
Article
País de afiliación:
Canadá