Three mechanisms in Escherichia coli rescue ribosomes stalled on non-stop mRNAs: one of them requires release factor 2.
Mol Microbiol
; 86(1): 6-9, 2012 Oct.
Article
en En
| MEDLINE
| ID: mdl-22909071
ABSTRACT
The tmRNA/SmpB system, which is almost universal in bacteria, rescues bacterial ribosomes stalled at the end of non-stop mRNAs (mRNAs lacking a stop codon). In addition, a few bacteria, including Escherichia coli, have developed a second two-component system as reported by Chadani et al. (2012). A small protein, ArfA of 55 amino acids (formerly called YdhL), mediates binding of release factor 2 to the ribosomal A site lacking a complete mRNA codon and thereby triggers translational termination and rescue of the stalled ribosome.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ribosomas
/
Aminoacil-ARN de Transferencia
/
Factores de Terminación de Péptidos
/
Proteínas de Unión al ARN
/
Proteínas de Escherichia coli
/
Escherichia coli
Idioma:
En
Revista:
Mol Microbiol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MICROBIOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Alemania