Potent inhibition of hepatitis B virus production in vitro by modified pyrimidine nucleosides.
Antimicrob Agents Chemother
; 34(10): 1986-90, 1990 Oct.
Article
en En
| MEDLINE
| ID: mdl-2291664
ABSTRACT
2',3'-Dideoxy-3'-fluorothymidine (FddThd), 2',3'-didehydro-2',3'- dideoxythymidine (ddeThd), and 3'-fluoro-5-methyl-deoxycytidine (FddMeCyt) are, in their triphosphate forms, selective inhibitors of human immunodeficiency virus type 1 reverse transcriptase. We report that 0.3 microM FddThd, FddMeCyt, or ddeThd as well as 3'-chloro-5-methyl-deoxycytidine (ClddMeCyt) or 3'-amino-5-methyl-deoxycytidine (AddMeCyt) almost completely blocked production of hepatitis B virus (HBV) particles by HBV DNA-transfected cell line 2.2.15 in vitro. Only at an at least 10-fold-higher concentration was a cytotoxic effect observed. These results indicate that FddThd, FddMeCyt, ClddMeCyt, AddMeCyt, and ddeThd are potent anti-HBV agents in vitro.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Nucleósidos de Pirimidina
/
ADN Viral
/
Virus de la Hepatitis B
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
1990
Tipo del documento:
Article