ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium.
Cancer Causes Control
; 23(11): 1805-10, 2012 Nov.
Article
en En
| MEDLINE
| ID: mdl-22961099
ABSTRACT
PURPOSE:
Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results.METHODS:
In eight studies participating in the Ovarian Cancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis.RESULTS:
Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk (OR 1.09; 95 % CI 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO OR 1.11; 95 % CI 1.01-1.22; p = 0.03; AA OR 1.03; 95 % CI 0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes.CONCLUSION:
Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Sistema del Grupo Sanguíneo ABO
/
Neoplasias Glandulares y Epiteliales
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Female
/
Humans
Idioma:
En
Revista:
Cancer Causes Control
Asunto de la revista:
EPIDEMIOLOGIA
/
NEOPLASIAS
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos