The first generation of ß-galactosidase-responsive prodrugs designed for the selective treatment of solid tumors in prodrug monotherapy.
Angew Chem Int Ed Engl
; 51(46): 11606-10, 2012 Nov 12.
Article
en En
| MEDLINE
| ID: mdl-22996951
ABSTRACT
Massive attack Galactoside prodrugs have been designed that can be selectively activated by lysosomal ß-galactosidase located inside cancer cells expressing a specific tumor-associated receptor. This efficient enzymatic process triggers a potent cytotoxic effect, releasing the potent antimitotic agent MMAE and allowing the destruction of both receptor-positive and surrounding receptor-negative tumor cells.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Profármacos
/
Beta-Galactosidasa
/
Aminobenzoatos
/
Neoplasias
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2012
Tipo del documento:
Article
País de afiliación:
Francia