Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells.
Nucleic Acid Ther
; 22(5): 295-305, 2012 Oct.
Article
en En
| MEDLINE
| ID: mdl-23030589
ABSTRACT
Gemcitabine is a nucleoside analog that is currently the best available single-agent chemotherapeutic drug for pancreatic cancer. However, efficacy is limited by our inability to deliver sufficient active metabolite into cancer cells without toxic effects on normal tissues. Targeted delivery of gemcitabine into cancer cells could maximize effectiveness and concurrently minimize toxic side effects by reducing uptake into normal cells. Most pancreatic cancers overexpress epidermal growth factor receptor (EGFR), a trans-membrane receptor tyrosine kinase. We utilized a nuclease resistant RNA aptamer that binds and is internalized by EGFR on pancreatic cancer cells to deliver gemcitabine-containing polymers into EGFR-expressing cells and inhibit cell proliferation in vitro. This approach to cell type-specific therapy can be adapted to other targets and to other types of therapeutic cargo.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Portadores de Fármacos
/
Desoxicitidina
/
Aptámeros de Nucleótidos
/
Receptores ErbB
/
Antimetabolitos Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Nucleic Acid Ther
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos