Capecitabine-induced hypertriglyceridemia and hyperglycemia: two cases.
Pharmacology
; 90(3-4): 212-5, 2012.
Article
en En
| MEDLINE
| ID: mdl-23038659
Capecitabine has shown significant antitumor activity against anthracycline/taxane refractory breast cancer and advanced colorectal carcinoma. The main drug-related adverse effects are palmar-plantar erythrodysesthesia (hand-foot syndrome), diarrhea and stomatitis. Dyslipidemia is a rare but important side effect of this drug. The mechanism of capecitabine-induced hypertriglyceridemia (CI-HTG) is unclear. It may be due to the decreased activities of lipoprotein lipase and hepatic triglyceride lipase. This report is associated with 2 patients who developed severe HTG when receiving capecitabine. Capecitabine was discountinued and antilipemic treatments were given and both cases are in follow-up with normal lipid levels. This report describes CI-HTG and possible pathogenetic mechanisms and the literature is reviewed.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hipertrigliceridemia
/
Desoxicitidina
/
Fluorouracilo
/
Hiperglucemia
/
Antimetabolitos Antineoplásicos
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Pharmacology
Año:
2012
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Suiza