DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker.
Carcinogenesis
; 34(1): 102-8, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-23054610
ABSTRACT
Using whole blood from 15 twin pairs discordant for breast cancer and high-resolution (450K) DNA methylation analysis, we identified 403 differentially methylated CpG sites including known and novel potential breast cancer genes. Confirming the results in an independent validation cohort of 21 twin pairs determined the docking protein DOK7 as a candidate for blood-based cancer diagnosis. DNA hypermethylation of the promoter region was also seen in primary breast cancer tissues and cancer cell lines. Hypermethylation of DOK7 occurs years before tumor diagnosis, suggesting a role as a powerful epigenetic blood-based biomarker as well as providing insights into breast cancer pathogenesis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Biomarcadores
/
Estudios en Gemelos como Asunto
/
Metilación de ADN
/
Epigénesis Genética
/
Proteínas Musculares
Límite:
Female
/
Humans
Idioma:
En
Revista:
Carcinogenesis
Año:
2013
Tipo del documento:
Article
País de afiliación:
España