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The role of the neuro-astro-vascular unit in the etiology of ataxia telangiectasia.
Meshulam, Leenoy; Galron, Ronit; Kanner, Sivan; De Pittà, Maurizio; Bonifazi, Paolo; Goldin, Miri; Frenkel, Dan; Ben-Jacob, Eshel; Barzilai, Ari.
Afiliación
  • Meshulam L; School of Physics and Astronomy, Tel Aviv University Ramat Aviv, Israel ; Sagol School of Neuroscience, Tel Aviv University Ramat Aviv, Israel ; Department of Neurobiology, Faculty of Life Sciences, Tel Aviv University Ramat Aviv, Israel.
Front Pharmacol ; 3: 157, 2012.
Article en En | MEDLINE | ID: mdl-23060792
ABSTRACT
The growing recognition that brain pathologies do not affect neurons only but rather are, to a large extent, pathologies of glial cells as well as of the vasculature opens to new perspectives in our understanding of genetic disorders of the CNS. To validate the role of the neuron-glial-vascular unit in the etiology of genome instability disorders, we report about cell death and morphological aspects of neuroglia networks and the associated vasculature in a mouse model of Ataxia Telangiectasia (A-T), a human genetic disorder that induces severe motor impairment. We found that A-T-mutated protein deficiency was consistent with aberrant astrocytic morphology and alterations of the vasculature, often accompanied by reactive gliosis. Interestingly similar findings could also be reported in the case of other genetic disorders. These observations bolster the notion that astrocyte-specific pathologies, hampered vascularization and astrocyte-endothelium interactions in the CNS could play a crucial role in the etiology of genome instability brain disorders and could underlie neurodegeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies Idioma: En Revista: Front Pharmacol Año: 2012 Tipo del documento: Article País de afiliación: Israel

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies Idioma: En Revista: Front Pharmacol Año: 2012 Tipo del documento: Article País de afiliación: Israel
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