Methylation of ELOVL2 gene as a new epigenetic marker of age.
Aging Cell
; 11(6): 1132-4, 2012 Dec.
Article
en En
| MEDLINE
| ID: mdl-23061750
ABSTRACT
The discovery of biomarkers able to predict biological age of individuals is a crucial goal in aging research. Recently, researchers' attention has turn toward epigenetic markers of aging. Using the Illumina Infinium HumanMethylation450 BeadChip on whole blood DNA from a small cohort of 64 subjects of different ages, we identified 3 regions, the CpG islands of ELOVL2, FHL2, and PENK genes, whose methylation level strongly correlates with age. These results were confirmed by the Sequenom's EpiTYPER assay on a larger cohort of 501 subjects from 9 to 99 years, including 7 cord blood samples. Among the 3 genes, ELOVL2 shows a progressive increase in methylation that begins since the very first stage of life (Spearman's correlation coefficient = 0.92) and appears to be a very promising biomarker of aging.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Precursores de Proteínas
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Acetiltransferasas
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Factores de Transcripción
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Envejecimiento
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Encefalinas
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Genoma Humano
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Epigénesis Genética
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Proteínas con Homeodominio LIM
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Proteínas Musculares
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Aging Cell
Año:
2012
Tipo del documento:
Article
País de afiliación:
Italia