A chiron approach to the total synthesis of (-)-juglomycin A, (+)-kalafungin, (+)-frenolicin B, and (+)-deoxyfrenolicin.
J Org Chem
; 77(22): 10455-60, 2012 Nov 16.
Article
en En
| MEDLINE
| ID: mdl-23088749
ABSTRACT
A general, efficient, and common strategy for the synthesis of (-)-juglomycin A, (+)-kalafungin, (+)-frenolicin B, and (+)-deoxyfrenolicin is reported here. The strategy involves the synthesis of a key building block alkyne from a cheap chiral pool material, D-glucono-δ-lactone, Dötz benzannulation, oxa-Pictet-Spengler reaction, and H(2)SO(4)-mediated epimerization.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Alquinos
Idioma:
En
Revista:
J Org Chem
Año:
2012
Tipo del documento:
Article
País de afiliación:
India