Migfilin, α-parvin and ß-parvin are differentially expressed in ovarian serous carcinoma effusions, primary tumors and solid metastases.
Gynecol Oncol
; 128(2): 364-70, 2013 Feb.
Article
en En
| MEDLINE
| ID: mdl-23099104
ABSTRACT
OBJECTIVE:
The objective of this study is to analyze the expression and clinical role of integrin-linked kinase (ILK), α-parvin, ß-parvin and migfilin in advanced-stage serous ovarian carcinoma.METHODS:
Expression of these 4 proteins was investigated in 205 effusions and in 94 patient-matched solid lesions (33 primary tumors and 61 solid metastases) using immunohistochemistry. Protein expression was analyzed for association with clinicopathologic parameters and survival.RESULTS:
ILK, α-parvin, ß-parvin and migfilin were expressed in tumor cells in 53%, 2%, 28% and 53% of effusions and 57%, 20%, 83% and 25% of solid lesions, respectively. Statistical analysis showed significantly higher α-parvin and ß-parvin expression in primary carcinomas (p=0.02 and p=0.001, respectively) and solid metastases (p=0.001 and p<0.001, respectively), compared to effusions, with opposite findings for migfilin (p=0.006 and p=0.008 for primary carcinomas and solid metastases, respectively). ILK expression was comparable at all anatomic sites. ß-Parvin expression in effusions was associated with better response to chemotherapy at diagnosis (p=0.014), with no other significant association with clinicopathologic parameters or survival. Expression in primary tumors and solid metastases was similarly unrelated to clinicopathologic parameters or survival.CONCLUSIONS:
This study provides further evidence to our previous observations that the adhesion profile of ovarian serous carcinoma cells in effusions differs from their counterparts in primary carcinomas and solid metastases. ß-Parvin may be a novel marker of chemoresponse in metastatic ovarian carcinoma.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Actinina
/
Líquido Ascítico
/
Moléculas de Adhesión Celular
/
Cistadenocarcinoma Seroso
/
Proteínas del Citoesqueleto
/
Proteínas de Microfilamentos
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Gynecol Oncol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Noruega