Measuring the glomerular filtration rate in different age groups using iohexol, the protocol from the Belgian iohexol study.
Clin Biochem
; 46(1-2): 31-6, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-23099194
OBJECTIVES: Measuring the exact glomerular filtration rate (GFR) is difficult. Iohexol can be used instead of inulin or labeled EDTA or DTPA. In recent years, different studies have validated GFR-estimating equations in adults. Validation of these estimations in adolescents and elderly is lacking. With this study, we aim to develop a simplified (only 1-3 blood collections) iohexol protocol to measure the true GFR for patients of all ages and try to develop GFR-estimating equations for adolescents and the elderly. DESIGN AND SETTING: Participants of different ages will be recruited: 50 adolescent (14-18 years) and 30 adults (20-65 years), 60 elderly (65-80 years) and 60 very elderly (80+ years old) stratified based on their GFR. Biometric data, serum creatinine and cystatin C will be measured. After injecting 5 mL iohexol, 9 blood samples will be taken between 20 and 360 min. First, the GFR will be calculated by using the double exponential decay method and different GFRs based on 1-3 blood samples, which will be compared with the GFR of the abovementioned 9 samples. Second, the GFR will be calculated by using new and existing equations and compared to the true GFR. DISCUSSION: The availability of a reliable GFR measurement is important in situations such as screening patients for kidney donation or when taking potentially nephrotoxic treatments. This study will allow us to develop a simplified protocol for measuring the true GFR in all ages and will allow us to validate existing equations and develop new eGFR equations for adolescents and the elderly.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Yohexol
/
Medios de Contraste
/
Tasa de Filtración Glomerular
Tipo de estudio:
Diagnostic_studies
/
Guideline
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
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Humans
/
Male
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Middle aged
Idioma:
En
Revista:
Clin Biochem
Año:
2013
Tipo del documento:
Article
País de afiliación:
Bélgica
Pais de publicación:
Estados Unidos