Early spread of hyperexcitability to caudal dorsal horn networks after a chemically-induced lesion of the rat spinal cord in vitro.
Neuroscience
; 229: 155-63, 2013 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-23103212
ABSTRACT
Hyperexcitability of dorsal horn neurons has been shown to play a key role in neuropathic pain following chronic experimental spinal cord injury. With a neonatal in vitro spinal cord injury model, we show that a chemically-induced lesion leads to rapid gain-of-function of sublesional dorsal horn networks biased to hyperexcitation. The expression of the GABA synthetic enzyme GAD65 was significantly reduced at the same level of the spinal cord, suggesting a compromised inhibitory system. We propose that our model could be useful to test early approaches to contrast spinal cord injury-induced central sensitization of dorsal horn circuits.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Médula Espinal
/
Traumatismos de la Médula Espinal
/
Células del Asta Posterior
Límite:
Animals
Idioma:
En
Revista:
Neuroscience
Año:
2013
Tipo del documento:
Article
País de afiliación:
Bélgica