Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation.
Chromosoma
; 121(6): 539-54, 2012 Dec.
Article
en En
| MEDLINE
| ID: mdl-23104094
ABSTRACT
The metazoan nucleus is disassembled and re-built at every mitotic cell division. The nuclear envelope, including nuclear pore complexes, breaks down at the beginning of mitosis to accommodate the capture of massively condensed chromosomes by the spindle apparatus. At the end of mitosis, a nuclear envelope is newly formed around each set of segregating and de-condensing chromatin. We review the current understanding of the membrane restructuring events involved in the formation of the nuclear membrane sheets of the envelope, the mechanisms governing nuclear pore complex assembly and integration in the nascent nuclear membranes, and the regulated coordination of these events with chromatin de-condensation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Poro Nuclear
/
Ensamble y Desensamble de Cromatina
/
Mitosis
/
Membrana Nuclear
Idioma:
En
Revista:
Chromosoma
Año:
2012
Tipo del documento:
Article
País de afiliación:
Alemania