A novel collection of snRNA-like promoters with tissue-specific transcription properties.
Int J Mol Sci
; 13(9): 11323-11332, 2012.
Article
en En
| MEDLINE
| ID: mdl-23109855
ABSTRACT
We recently identified a novel dataset of snRNA-like trascriptional units in the human genome. The investigation of a subset of these elements showed that they play relevant roles in physiology and/or pathology. In this work we expand our collection of small RNAs taking advantage of a newly developed algorithm able to identify genome sequence stretches with RNA polymerase (pol) III type 3 promoter features thus constituting putative pol III binding sites. The bioinformatic analysis of a subset of these elements that map in introns of protein-coding genes in antisense configuration suggest their association with alternative splicing, similarly to other recently characterized small RNAs. Interestingly, the analysis of the transcriptional activity of these novel promoters shows that they are active in a cell-type specific manner, in accordance with the emerging body of evidence of a tissue/cell-specific activity of pol III.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Especificidad de Órganos
/
Transcripción Genética
/
ARN Polimerasa III
/
ARN Nuclear Pequeño
/
Regiones Promotoras Genéticas
Límite:
Humans
Idioma:
En
Revista:
Int J Mol Sci
Año:
2012
Tipo del documento:
Article
País de afiliación:
Italia