Effect of opioid peptides on the content of LPO products and antioxidant enzyme activity in the liver of rats after restraint stress.

Administration of opioid peptides dynorphin A (1-13) and DSLET was followed by a decrease in the stress-induced activation of LPO and increase in SOD activity in the liver tissue of rats. DAGO produced a similar, but less pronounced effect. The observed changes can be related to a specific distribution of opioid receptors in the liver tissue and stress-limiting influence of these peptides in the whole body.