Evaluation of a ketamine-propofol drug combination with or without dexmedetomidine for intravenous anesthesia in cats undergoing ovariectomy.
J Am Vet Med Assoc
; 241(10): 1307-13, 2012 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-23113522
ABSTRACT
OBJECTIVE:
To evaluate the use of a ketamine-propofol combination, with or without dexmedetomidine, in cats undergoing ovariectomy and to assess Heinz body formation following administration of these drugs.DESIGN:
Randomized clinical trial. ANIMALS 15 client-owned female cats. PROCEDURES Anesthesia was induced with a ketamine (2.0 mg/kg [0.91 mg/lb])-propofol (2.0 mg/kg) combination with (n = 7) or without (8) dexmedetomidine (0.003 mg/kg [0.0013 mg/lb]) and was maintained via continuous IV infusion of a 11 ketamine-propofol combination (administration rate for each drug, 10.0 mg/kg/h [4.54 mg/lb/h]). Cats underwent ovariectomy; duration of infusion was 25 minutes. Physiologic variables were measured at predetermined time points. Heinz bodies were quantified via examination of blood smears. Numeric scales were used to assess quality of recovery, degree of sedation, and signs of pain after surgery.RESULTS:
The ketamine-propofol group had a significantly higher mean heart rate at several time points during drug infusion, a significantly shorter time from the end of infusion to extubation (7 vs 29 minutes), and significantly lower sedation scores for the first hour after surgery than did the ketamine-propofol-dexmedetomidine group. Other variables were similar between groups; recovery was smooth, and anesthesia and postoperative analgesia were deemed adequate for all cats. The number of RBCs with Heinz bodies was not increased after surgery, compared with values immediately after anesthetic induction. CONCLUSIONS AND CLINICAL RELEVANCE Total IV anesthesia with a ketamine-propofol combination, with or without dexmedetomidine, appeared to be effective in healthy cats. These short-term infusions produced smooth recovery and adequate analgesia during the postoperative period.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ovariectomía
/
Gatos
/
Propofol
/
Dexmedetomidina
/
Ketamina
/
Anestesia Intravenosa
Límite:
Animals
Idioma:
En
Revista:
J Am Vet Med Assoc
Año:
2012
Tipo del documento:
Article
País de afiliación:
Italia