Detection of IL-6 by magnetic nanoparticles grown with the assistance of mid-infrared lighting.
Mol Med Rep
; 7(1): 73-6, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-23117195
ABSTRACT
Nanomedical systems have attracted considerable attention primarily due to suitability in applications for specific cell selection through biomolecular targeting and rare cell detection enhancement in a diverse, multicellular population. In the present study, magnetic nanoparticles were prepared for use in high accuracy cell sensing. Magnetic nanoparticle growth was assisted by mid-infrared lighting. By this mechanism, a narrow window, estimated to be 2%, was achieved for the dimension distribution of grown nanoparticles. Combined with silicon nanowire (SiNW) transistors, a sensor with ultra high sensitivity for the detection of specific potential low abundance biomarkers has been achieved, which has been specifically used to detect interleukin-6 (IL-6) at extremely low concentrations. A novel biosensor with high sensitivity has been fabricated and utilized in the detection of IL-6 at 75 fM to 50 pM. The system consists of an SiNW transistor and magnetic nanoparticles with even dimension distribution. The novel sensor system is suitable for quantifying IL-6 at low concentrations in protein samples.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Técnicas Biosensibles
/
Interleucina-6
/
Nanopartículas de Magnetita
/
Rayos Infrarrojos
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Mol Med Rep
Año:
2013
Tipo del documento:
Article