Enhanced costimulation by CD70+ B cells aggravates experimental autoimmune encephalomyelitis in autoimmune mice.
J Neuroimmunol
; 255(1-2): 8-17, 2013 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-23137837
ABSTRACT
OBJECTIVE:
Assess whether CD70+ B cells contribute to EAE. MATERIALS ANDMETHODS:
MOG-specific TCR transgenic mice (2D2) were crossed with mice with constitutive CD70 expression on B cells. The development of EAE and the phenotype of B-T lymphocytes were studied in 2D2xCD70 animals.RESULTS:
Spontaneous EAE developed in 20% of 2D2xCD70 and 3% of 2D2 mice. EAE was also more severe in 2D2xCD70 versus 2D2 animals upon MOG immunization. The susceptibility of 2D2xCD70 to EAE was associated with fewer FoxP3+ T cells.CONCLUSIONS:
Expression of CD70 by B cells aggravates EAE possibly by reducing the number of regulatory T cells.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Subgrupos de Linfocitos B
/
Encefalomielitis Autoinmune Experimental
/
Ligando CD27
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Países Bajos