Palliative intralesional interleukin-2 treatment in dogs with urinary bladder and urethral carcinomas.
In Vivo
; 26(6): 931-5, 2012.
Article
en En
| MEDLINE
| ID: mdl-23160674
ABSTRACT
AIM:
The investigation of the influence of intralesional interleukin-2 (IL-2) on the clinical course and tumor progression in dogs suffering from urinary bladder and urethral carcinomas. MATERIALS ANDMETHODS:
Medical records of 25 dogs diagnosed with advanced transitional cell carcinomas (TCC) were retrospectively reviewed. In 14 dogs, intralesional IL-2 treatment was performed by transabdominal ultrasound-guided injection. Seven dogs underwent cytoreductive surgery, followed by IL-2 injection into the tumor bed. All dogs received long-term non-steroidal anti-inflammatory drugs.RESULTS:
Adverse effects associated with IL-2 treatment were not observed. At re-examination, 17 dogs showed marked clinical improvement and regression of tumor size. Four dogs were in complete remission.CONCLUSION:
Intralesional IL-2 application is a safe and minimally-invasive palliative treatment option in dogs suffering from advanced transitional cell carcinoma when surgical cure is impossible. Prognosis depends on tumor localization and feasibility of concomitant cytoreductive surgery.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Uretrales
/
Neoplasias de la Vejiga Urinaria
/
Carcinoma
/
Interleucina-2
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
In Vivo
Asunto de la revista:
NEOPLASIAS
Año:
2012
Tipo del documento:
Article
País de afiliación:
Alemania