Elevated uric acid and functional mitral regurgitation in dilated cardiomyopathy.
Eur Rev Med Pharmacol Sci
; 16(12): 1637-41, 2012 Nov.
Article
en En
| MEDLINE
| ID: mdl-23161034
ABSTRACT
BACKGROUND:
Recent findings suggest that there is a close relationship between chronic heart failure and uric acid.AIMS:
The aim of the study was to assess whether increased uric acid levels in patients with dilated cardiomyopathy might correlate with the degree of functional mitral regurgitation (MR). MATERIALS ANDMETHODS:
Sixty two consecutive patients diagnosed with dilated cardiomyopathy were included in the study. The patients were classified according to severity of functional MR into two groups mild-moderate functional MR (ERO < 0.2 cm2) and severe functional MR.RESULTS:
The patients with severe functional MR had significantly higher serum uric acid levels compared to patients without severe functional MR (6.34 ± 1.61 mg/dL vs 5.43 ± 1.17 mg/dL respectively, p = 0.012). Furthermore, tenting area, an important predictor of functional MR severity, was moderately correlated with the serum uric acid levels (r = 0.351, p = 0.005). It was also shown that the serum uric acid concentrations were inversely correlated with left ventricular (LV) ejection fraction, and positively correlated with LV volumes. There was also a significant relation between the serum uric acid and left atrial volumes and also brain natriuretic peptide (BNP) levels.CONCLUSIONS:
In conclusion, this study demonstrates that elevated serum uric acid levels in patients with dilated cardiomyopathy are correlated with the severity of functional MR and echocardiographic volume indices.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Úrico
/
Cardiomiopatía Dilatada
/
Insuficiencia de la Válvula Mitral
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur Rev Med Pharmacol Sci
Asunto de la revista:
FARMACOLOGIA
/
TOXICOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Turquía